02/07/2025
research article
Introduction of the RiboFlip cassette as a flexible tool to control endogenous gene expression in a vertebrate model and as an alternative to existing conditional knockdown strategies.
Image credit: pgen.1011594
Current Issue December 2024
02/10/2025
research article
The authors established a library of induced pluripotent stem cells (iPSCs) derived from Tibetan and Han Chinese individuals, a robust model system allowing precise exploration of allelic effects on transcriptional responses, and we differentiated them into vascular endothelium.
Image credit: pgen.1011570
02/12/2025
research article
Hybridization can significantly influence the recombination landscape, and that the reduction in allele shuffling contributes to the initial purging of introgression in the generations following a hybridization event.
Image credit: CDC/ Dr. Hardin
01/10/2025
research article
metaGE identifies QTLs, providing valuable insights into the genetic architecture of complex traits and QTL effects and the statistical approach is available as an R package.
Image credit: pgen.1011553
01/07/2025
methods
mr.mash is a multi-phenotype method that improves the accuracy of predictions by using methods that model multiple phenotypes jointly and account for shared effects.
Image credit: pgen.1011519
01/21/2025
research article
This study reveals new mechanisms by which clinically distinct DDX3X missense mutations differentially impair neurodevelopment.
Image credit: pgen.1011555
12/02/2024
research article
This study shows the correlation of neurological severity with the type, location, and cellular function of XPA germline pathogenic variants
Image credit: pgen.1011265
12/16/2024
RESEARCH article
This work highlights unique issues that arise when using PCA to control for ancestral heterogeneity in admixed populations and demonstrates the importance of pre-processing and diagnostics.
Image credit: pgen.1011242
12/02/2024
Research Article
PIP2 can specifically bind BRD4 and PIP2 levels affect number of BRD2 foci at the nucleus.
Image credit: pgen.1011462
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