Charles I. White offers his Perspective on two articles by Liudmila Chelysheva et al. and Frank Hartung et al., in which they offer new data and further understanding of the meiotic anti–crossing-over function of the Blap75/Rmi1 and Topoisomerase 3α proteins.
The authors conclude that the clustering of sodium channels on axons was the initial pivotal step in a chordate-specific series of evolutionary innovations, making nerve impulses more rapid and robust.
This work suggests that GMAP210 and IFT20 function together at the Golgi complex in the sorting or transport of proteins destined for the ciliary membrane.
These results establish a genetic cascade in which Gata3 acts downstream of β-catenin, but upstream of Ret, to prevent ectopic ureter budding and premature cell differentiation in the nephric duct.
PLoS Biology; PLoS Medicine; PLoS Computational Biology; PLoS Pathogens; PLoS ONE; PLoS Neglected Tropical Diseases
PLoS Biology; PLoS Medicine; PLoS Computational Biology; PLoS Neglected Tropical Diseases
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