'Our conversation ranged from tiny triplet repeats to large and complicated duplications, some of which harbor genes of uniquely human import, and the process of their discoveries.' Read more in Jane Gitschier's Interview with Evan Eichler.
This study provides additional evidence for widespread positive selection in mammalian evolution and new genome-wide insights into the functional implications of positive selection.
These data reveal an intriguing system for regulated nuclear transport of a cargo protein that does not contain a nuclear export sequence of its own.
The authors conclude that whole-genome sequencing can drastically accelerate the identification of suppressor mutations and complex genetic interactions, and that it can be applied as a standard tool to investigate the genetic traits of model organisms. 'Rise of the Machines' accompanies this research.
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PLoS Biology; PLoS Medicine; PLoS Computational Biology; PLoS Neglected Tropical Diseases
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